(Ph Eur monograph 0007)
Ammonium chloride contains not less than 99.0 per cent and not
more than the equivalent of 100.5 per cent of NH4Cl, calculated with reference
to the dried substance.
A white, crystalline powder or colourless crystals, freely
soluble in water.
gives the reactions of chlorides (2.3.1).
ml of solution S (see Tests) gives the reaction of ammonium salts (2.3.1).
Dissolve 10.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 100 ml with the same solvent.
Appearance of solution
Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
Acidity or alkalinity
To 10 ml of solution S add 0.05 ml of methyl red solution R.
Not more than 0.5 ml of 0.01M hydrochloric
acid or 0.01M sodium
hydroxide is required to change the colour of the indicator.
Bromides and iodides
To 10 ml of solution S add 0.1 ml of dilute hydrochloric
acid R and 0.05 ml of chloramine solution R. After 1 min, add 2 ml of chloroform
R and shake vigorously. The chloroform layer remains colourless (2.2.2, Method I).
10 ml of solution S diluted to 15 ml with distilled water R complies with the limit test for sulphates
5 ml of solution S diluted to 15 ml with distilled water R complies with the limit test for calcium
5 ml of solution S diluted to 10 ml with water R complies with the limit test for iron (20
Heavy metals (2.4.8)
12 ml of solution S complies with limit test A (10 ppm).
Prepare the standard using lead standard solution (1 ppm Pb) R.
Loss on drying (2.2.32)
Not more than 1.0 per cent, determined on 1.00 g by drying in
an oven at 100-105C for 2 h.
Sulphated ash (2.4.14)
Not more than 0.1 per cent, determined on 2.0 g.
Dissolve 1.000 g in 20 ml of water R and add a mixture of 5 ml of formaldehyde
solution R, previously neutralised to phenolphthalein solution R, and 20 ml of water R. After 1 min to 2 min, titrate slowly with 1M sodium
hydroxide, using a further 0.2 ml of the same indicator.
1 ml of 1M sodium
hydroxide is equivalent to 53.49 mg of NH4Cl.
Action and use
Used for the acidification of urine and to correct metabolic
Ammonium Chloride Mixture