Oral Liquids of the British Pharmacopoeia

In addition to the above requirements of the European Pharmacopoeia, the following statements apply to any elixir, linctus, mixture, oral drops, oral emulsion, oral solution, oral suspension or syrup that is the subject of an individual monograph in the British Pharmacopoeia.

 

Definition

 

The vehicle for any particular Oral Liquid should be chosen having regard to the nature of the active ingredient or ingredients and to provide organoleptic characteristics appropriate to the intended use of the preparation.

 

Oral Liquids other than Oral Emulsions may be supplied as liquids or prepared just before issue for use by dissolving or dispersing granules or powder in the liquid stated on the label.

 

Labelling

 

The label states (1) the date after which the Oral Liquid is not intended to be used; (2) the conditions under which the Oral Liquid should be stored; (3) for Oral Emulsions, Oral Suspensions and, where appropriate, for Mixtures, that the bottle should be shaken before use.

 

If the Oral Liquid is supplied as granules or powder to be constituted just before issue for use the label states (1) that the contents of the container are granules or powder for the preparation of an Oral Liquid; (2) the strength as the amount of the active ingredient in a suitable dose-volume of the constituted preparation; (3) the directions for preparing the Oral Liquid including the nature and quantity of liquid to be used.

 

ELIXIRS

 

Definition

 

Elixirs are clear , flavoured Oral Liquids containing one or more active ingredients dissolved in a vehicle that usually contains a high proportion of Sucrose or a suitable polyhydric alcohol or alcohols and may also contain Ethanol (96 per cent) or a Dilute Ethanol.

 

LINCTUSES

 

Definition

 

Linctuses are viscous Oral Liquids that may contain one or more active ingredients in solution. The vehicle usually contains a high proportion of Sucrose, other sugars or a suitable polyhydric alcohol or alcohols. Linctuses are intended for use in the treatment or relief of cough, and are sipped and swallowed slowly without the addition of water.

 

MIXTURES

 

Definition

 

Mixtures are Oral Liquids containing one or more active ingredients dissolved, suspended or dispersed in a suitable vehicle. Suspended solids may separate slowly on standing but are easily redispersed on shaking.

 

ORAL DROPS

 

Definition

 

Oral Drops are Oral Liquids that are intended to be administered in small volumes with the aid of a suitable measuring device.

 

ORAL EMULSIONS

 

Definition

 

Oral Emulsions are Oral Liquids containing one or more active ingredients. They are stabilised oil-in-water dispersions, either or both phases of which may contain dissolved solids. Solids may also be suspended in Oral Emulsions.

 

When issued for use, Oral Emulsions should be supplied in wide-mouthed bottles.

 

Extemporaneous preparation

 

In Oral Emulsions prepared according to the formula and directions given for Extemporaneous preparation, the quantity of emulsifying agent specified in individual monographs may be reduced to yield a preparation of suitable consistency provided that by so doing the stability of the preparation is not adversely affected.

 

ORAL SOLUTIONS

 

Definition

 

Oral Solutions are Oral Liquids containing one or more active ingredients dissolved in a suitable vehicle.

 

ORAL SUSPENSIONS

 

Definition

 

Oral Suspensions are Oral Liquids containing one or more active ingredients suspended in a suitable vehicle. Suspended solids may slowly separate on standing but are easily redispersed.

 

SYRUPS

 

Definition

 

Syrups do not contain active ingredients. They are not intended to be administered as such but are used as vehicle ingredients for their flavouring and sweetening properties.

 

Production

 

Syrups should be recently prepared unless they contain suitable antimicrobial preservatives.

 

Storage

 

Syrups should be stored at temperatures not exceeding 30.

 

Labelling

 

The label states (1) the date after which the Syrup is not intended to be used; (2) the conditions under which the Syrup should be stored.

 

The following oral liquids are the subject of an individual monograph in the British Pharmacopoeia.

 

Elixirs

 

Ephedrine Elixir

 

Phenobarbital Elixir

 

Piperazine Citrate Elixir

 

Linctuses

 

Codeine Linctus

 

Codeine Linctus, Paediatric

 

Methadone Linctus

 

Pholcodine Linctus

 

Pholcodine Linctus, Strong

 

Simple Linctus

 

Simple Linctus, Paediatric

 

Squill Linctus, Opiate

 

Squill Linctus, Paediatric Opiate

 

Tolu Linctus, Paediatric Compound

 

Mixtures

 

Ammonium Chloride Mixture

 

Gentian Mixture, Acid

 

Gentian Mixture, Alkaline

 

Ipecacuanha Emetic Mixture, Paediatric

 

Kaolin and Morphine Mixture

 

Kaolin Mixture

 

Magnesium Carbonate Mixture, Aromatic

 

Magnesium Hydroxide Mixture

 

Magnesium Sulphate Mixture

 

Magnesium Trisilicate Mixture

 

Potassium Citrate Mixture

 

Oral Drops

 

Sodium Fluoride Oral Drops

 

Vitamins A, C and D Oral Drops, Paediatric

 

Oral Emulsions

 

Liquid Paraffin Oral Emulsion

 

Liquid Paraffin and Magnesium Hydroxide Oral Emulsion

 

Oral Solutions

 

Alimemazine Oral Solution, Paediatric

 

Alimemazine Oral Solution, Strong Paediatric

 

Amantadine Oral Solution

 

Atenolol Oral Solution

 

Baclofen Oral Solution

 

Bumetanide Oral Solution

 

Chlorphenamine Oral Solution

 

Chlorpromazine Oral Solution

 

Cimetidine Oral Solution

 

Clemastine Oral Solution

 

Clomethiazole Oral Solution

 

Co-amilozide Oral Solution

 

Codeine Phosphate Oral Solution

 

Diazepam Oral Solution

 

Dicycloverine Oral Solution

 

Digoxin Oral Solution, Paediatric

 

Dihydrocodeine Oral Solution

 

Diphenhydramine Oral Solution

 

Docusate Oral Solution

 

Docusate Oral Solution, Paediatric

 

Ethosuximide Oral Solution

 

Ferrous Sulphate Oral Solution, Paediatric

 

Flucloxacillin Oral Solution

 

Fluoxetine Oral Solution

 

Haloperidol Oral Solution

 

Haloperidol Oral Solution, Strong

 

Iodine Oral Solution, Aqueous

 

Lithium Citrate Oral Solution

 

Methadone Oral Solution (1 mg per ml)

 

Metoclopramide Oral Solution

 

Neomycin Oral Solution

 

Orciprenaline Oral Solution

 

Paracetamol Oral Solution, Paediatric

 

Phenoxymethylpenicillin Oral Solution

 

Prochlorperazine Oral Solution

 

Promethazine Oral Solution

 

Ranitidine Oral Solution

 

Selegiline Oral Solution

 

Sodium Feredetate Oral Solution

 

Sodium Valproate Oral Solution

 

Temazepam Oral Solution

 

Thioridazine Oral Solution

 

Triclofos Oral Solution

 

Oral Suspensions

 

Aciclovir Oral Suspension

 

Aluminium Hydroxide Oral Suspension

 

Amoxicillin Oral Suspension

 

Amphotericin Oral Suspension

 

Ampicillin Oral Suspension

 

Barium Sulphate Oral Suspension

 

Benorilate Oral Suspension

 

Cefaclor Oral Suspension

 

Cefadroxil Oral Suspension

 

Cefalexin Oral Suspension

 

Cefradine Oral Suspension

 

Cimetidine Oral Suspension

 

Co-fluampicil Oral Suspension

 

Co-magaldrox Oral Suspension

 

Co-trimoxazole Oral Suspension

 

Co-trimoxazole Oral Suspension, Paediatric

 

Erythromycin Ethyl Succinate Oral Suspension

 

Ferrous Fumarate Oral Suspension

 

Flucloxacillin Oral Suspension

 

Fusidic Acid Oral Suspension

 

Ibuprofen Oral Suspension

 

Magaldrate Oral Suspension

 

Metronidazole Oral Suspension

 

Nabumetone Oral Suspension

 

Nalidixic Acid Oral Suspension

 

Naproxen Oral Suspension

 

Nitrazepam Oral Suspension

 

Nitrofurantoin Oral Suspension

 

Nystatin Oral Suspension

 

Paracetamol Oral Suspension

 

Phenytoin Oral Suspension

 

Primidone Oral Suspension

 

Promazine Oral Suspension

 

Rifampicin Oral Suspension

 

Simeticone Suspension for Infants

 

Terfenadine Oral Suspension

 

Thioridazine Oral Suspension

 

Trimethoprim Oral Suspension

 

Syrups

 

Black Currant Syrup

 

Invert Syrup

 

Lemon Syrup

 

Orange Syrup

 

Syrup

 

Tolu Syrup