Carbamide Peroxide
;)
Urea,compd.with hydrogen peroxide (1:1).
Urea compound with hydrogen peroxide (1:1) [124-43-6].
»Carbamide Peroxide contains not less than 96.0percent and not more than 102.0percent of CH6N2O3.
Packaging and storage—
Preserve in tight,light-resistant containers,and avoid exposure to excessive heat.
Identification—
A:
Mix 1mLof a solution (1in 10)of it with 1mLof nitric acid:a white,crystalline precipitate is formed.
B:
Asolution of it (1in 10)responds to the tests for Peroxide á191ñ.
Organic volatile impurities,Method Iá467ñ:
meets the requirements.
Assay—
Transfer about 100mg of Carbamide Peroxide,accurately weighed,to a 500-mLiodine flask with the aid of 25mLof water,add 5mLof glacial acetic acid,and mix.Add 2g of potassium iodide and 1drop of ammonium molybdate TS,insert the stopper,and allow to stand in the dark for 10minutes.Titrate the liberated iodine with 0.1Nsodium thiosulfate VS,adding 3mLof starch TSas the endpoint is approached.Each mLof 0.1Nsodium thiosulfate is equivalent to 4.704mg of CH6N2O3.
Auxiliary Information—
Staff Liaison:Karen A Russo,Ph.D.,Scientist
Expert Committee:(PA1)Pharmaceutical Analysis 1
USP28–NF23Page 345
Phone Number:1-301-816-8379