Carbomer 934
»Carbomer 934is a high molecular weight polymer of acrylic acid cross-linked with allyl ethers of sucrose.Carbomer 934,previously dried in vacuum at 80
for 1hour,contains not less than 56.0percent and not more than 68.0percent of carboxylic acid (–COOH)groups.The viscosity of a neutralized 0.5percent aqueous dispersion of Carbomer 934is between 30,500and 39,400centipoises.
for 1hour,contains not less than 56.0percent and not more than 68.0percent of carboxylic acid (–COOH)groups.The viscosity of a neutralized 0.5percent aqueous dispersion of Carbomer 934is between 30,500and 39,400centipoises.
Packaging and storage—
Preserve in tight containers.
Labeling—
Label it to indicate that it is not intended for internal use.
Viscosity—
Proceed as directed in the test for Viscosityunder Carbomer 934P.It is between 30,500and 39,400centipoises.
Limit of benzene—
Proceed as directed in the test for Limit of benzeneunder Carbomer 934P,except to use about 20mg of Carbomer 934,accurately weighed,instead of about 1g of Carbomer 934P,to prepare the Test solution.Calculate the percentage of benzene in the portion of Carbomer 934taken by the formula:
10(C/W)(rU/rS),
in which Cis the concentration,in µg per mL,of benzene in the Standard solution,Wis the weight,in mg,of Carbomer 934taken to prepare the Test solution,and rUand rSare the benzene peak responses obtained from the Test solutionand the Standard solution,respectively:not more than 0.5%is found.
Other requirements—
It meets the requirements for Identification,Loss on drying,Heavy metals,and Assay for carboxylic acid contentunder Carbomer 934P.
Auxiliary Information—
Staff Liaison:Catherine Sheehan,B.Sc.,Scientist
Expert Committee:(EMC)Excipients:Monograph Content
USP28–NF23Page 2972
Phone Number:1-301-816-8262