Aminohippuric Acid
;)
Glycine,N-(4-aminobenzoyl)-.
p-Aminohippuric acid [61-78-9].
»Aminohippuric Acid contains not less than 98.0percent and not more than 100.5percent of C9H10N2O3,calculated on the dried basis.
Packaging and storage—
Preserve in tight,light-resistant containers.
Identification—
A:
Infrared Absorption á197Kñ.
B:
Dissolve about 10mg in 5mLof water,and add 0.5mLof 3Nhydrochloric acid,0.5mLof sodium nitrite solution (1in 10),and a solution of 0.20g of 2-naphthol in 10mLof 6Nammonium hydroxide:a red color is produced.
Loss on drying á731ñ—
Dry it at 105
for 2hours:it loses not more than 0.25%of its weight.
for 2hours:it loses not more than 0.25%of its weight.
Residue on ignition á281ñ:
not more than 0.25%.
Heavy metals,Method IIá231ñ:
0.001%.
Assay—
Transfer about 150mg,accurately weighed,of Aminohippuric Acid to a beaker or a casserole.Add 5mLof hydrochloric acid and 50mLof water,and proceed as directed under Nitrite Titration á451ñ,beginning with “stir until dissolved.”Each mLof 0.1Msodium nitrite is equivalent to 19.42mg of C9H10N2O3.
Auxiliary Information—
Staff Liaison:Larry N.Callahan,Ph.D.,Scientist
Expert Committee:(BNT)Biotechnology and Natural Therapeutics/Diagnostics
USP28–NF23Page 127
Phone Number:1-301-816-8385