Ethyl Vanillin, chemical structure, molecular formula, Reference Standards

Ethyl Vanillin

C9H10O3 166.17

Benzaldehyde,3-ethoxy-4-hydroxy-.
3-Ethoxy-4-hydroxybenzaldehyde [121-32-4].

»Ethyl Vanillin,dried over phosphorus pentoxide for 4hours,contains not less than 98.0percent and not more than 101.0percent of C9H10O3.

Packaging and storage— Preserve in tight,light-resistant containers.

USP Reference standards á11ñ— USP Ethyl Vanillin RS.

Identification—

A: Infrared Absorption á197Kñ.

B: Ultraviolet Absorption á197Uñ—

Solution: 8µg per mL.

Medium: methanol.

Melting range á741ñ: between 76

and 78

Loss on drying á731ñ— Dry it over phosphorus pentoxide for 4hours:it loses not more than 1.0%of its weight.

Residue on ignition á281ñ: not more than 0.1%.

Organic volatile impurities,Method IVá467ñ: meets the requirements.

Assay— Dissolve about 300mg of Ethyl Vanillin,previously dried and accurately weighed,in 50mLof dimethylformamide contained in a 125-mLconical flask.Add thymol blue TS,and titrate with 0.1Nsodium methoxide VS,using a magnetic stirrer and taking precautions against the absorption of atmospheric carbon dioxide.Perform a blank determination,and make any necessary correction.Each mLof 0.1Nsodium methoxide is equivalent to 16.62mg of C9H10O3.

Auxiliary Information— Staff Liaison:Catherine Sheehan,B.Sc.,Scientist

Expert Committee:(EMC)Excipients:Monograph Content

USP28–NF23Page 3003

Phone Number:1-301-816-8262