Idoxuridine
;)
Uridine,2¢-deoxy-5-iodo-.
2¢-Deoxy-5-iodouridine [54-42-2].
»Idoxuridine contains not less than 98.0percent and not more than 101.0percent of C9H11IN2O5,calculated on the dried basis.
Packaging and storage—
Preserve in tight,light-resistant containers.
Identification—
A:Infrared Absorption á197Mñ.
B:Ultraviolet Absorption á197Uñ—
Solution:
35µg per mL.
Medium:
pH12.0buffer (prepared from 7.46g of potassium chloride and 24mLof 1Nsodium hydroxide dissolved in 2000mLof water).
Absorptivities at 279nm,calculated on the dried basis for the test sample only,do not differ by more than 2.0%.
Loss on drying á731ñ—
Dry about 500mg,accurately weighed,in vacuum at 60
for 2hours:it loses not more than 1.0%of its weight.
for 2hours:it loses not more than 1.0%of its weight.
Assay—
Dissolve about 250mg of Idoxuridine,accurately weighed,in 20mLof dimethylformamide that previously has been neutralized with 0.1Nsodium methoxide in toluene VS,a solution of 300mg of thymol blue in 100mLof methanol being used as the indicator.Titrate with 0.1Nsodium methoxide in toluene VSto a blue endpoint,taking precautions against absorption of atmospheric carbon dioxide.Perform a blank determination,and make any necessary correction.Each mLof 0.1Nsodium methoxide is equivalent to 35.41mg of C9H11IN2O5.
Auxiliary Information—
Staff Liaison:Behnam Davani,Ph.D.,MBA,Senior Scientist
Expert Committee:(PA7)Pharmaceutical Analysis 7
USP28–NF23Page 997
Pharmacopeial Forum:Volume No.29(4)Page 1033
Phone Number:1-301-816-8394