Isopropyl Alcohol
;)
2-Propanol.
Isopropyl alcohol [67-63-0].
»Isopropyl Alcohol contains not less than 99.0percent of C3H8O.
Packaging and storage—
Preserve in tight containers,remote from heat.
Identification—
The IRabsorption spectrum of a thin film of it exhibits a strong broad band at 3.0µm;a strong region of absorption between 3.35and 3.5µm,with its highest peak at about 3.36µm,and others at about 3.41and 3.47µm;a strong region of absorption between 6.7and 7.8µm,the most prominent features being the peaks at about 6.80,7.10,7.25(the highest),7.50,and 7.65µm;a strong region of absorption between 8.5and 9.2µm,peaking at about 8.6,8.85,and 9.0µm;and strong peaks at about 10.5and 12.3µm.
Specific gravity á841ñ:
between 0.783and 0.787.
Refractive index á831ñ:
between 1.376and 1.378at 20
.
.
Acidity—
To 50mLin a suitable flask add 100mLof carbon dioxide-free water.Add 2drops of phenolphthalein TS,and titrate with 0.020Nsodium hydroxide to a pink color that persists for 30seconds:not more than 0.70mLof 0.020Nsodium hydroxide is required for neutralization.
Limit of nonvolatile residue—
Evaporate 50mLin a tared porcelain dish on a steam bath to dryness,and heat at 105for 1hour:the weight of the residue does not exceed 2.5mg (0.005%).
for 1hour:the weight of the residue does not exceed 2.5mg (0.005%).
Assay—
Inject about 5µLof Isopropyl Alcohol into a suitable gas chromatograph,equipped with a thermal conductivity detector.Under typical conditions,the gas chromatograph contains a 1.8-m ×6.4-mm (OD)stainless steel column packed with 10%liquid phase G20on support S1A,the column is maintained at 55,and helium is used as the carrier gas at a flow rate of 45mLper minute.Relative retention times of some of the possible components,when present,are:air at 0.09,diethyl ether at 0.14,diisopropyl ether at 0.17,acetone at 0.37,isopropyl alcohol at 1.00,2-butanol at 1.64,n-propyl alcohol at 1.86,and water at 3.14.Calculate the percentage of C3H8Oin the Isopropyl Alcohol by dividing the area under the isopropyl alcohol peak by the sum of the areas under all of the peaks observed,and multiplying by 100.
,and helium is used as the carrier gas at a flow rate of 45mLper minute.Relative retention times of some of the possible components,when present,are:air at 0.09,diethyl ether at 0.14,diisopropyl ether at 0.17,acetone at 0.37,isopropyl alcohol at 1.00,2-butanol at 1.64,n-propyl alcohol at 1.86,and water at 3.14.Calculate the percentage of C3H8Oin the Isopropyl Alcohol by dividing the area under the isopropyl alcohol peak by the sum of the areas under all of the peaks observed,and multiplying by 100.
Auxiliary Information—
Staff Liaison:Behnam Davani,Ph.D.,MBA,Senior Scientist
Expert Committee:(PA7)Pharmaceutical Analysis 7
USP28–NF23Page 1077
Phone Number:1-301-816-8394