Antimony Potassium Tartrate
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Antimonate(2-),bis[µ-[2,3-dihydroxybutanedioato(4-)-O1,O2:O3,O4]]-di-,dipotassium,trihydrate,stereoisomer.
Dipotassium bis[µ-[L-(+)-tartrato(4-)]]diantimonate(2-)trihydrate [28300-74-5].
Anhydrous 613.82 [11071-15-1].
»Antimony Potassium Tartrate contains not less than 99.0percent and not more than 103.0percent of C8H4K2O12Sb2·3H2O.
Packaging and storage—
Preserve in well-closed containers.
Completeness of solution á641ñ:
meets the requirements,using a 750-mg specimen and water as the solvent.
Identification—
A:
When heated to redness,it chars,emits an odor resembling that of burning sugar,and leaves a blackened residue.This residue has an alkaline reaction,and when a small fragment of it is held in a nonluminous flame,the flame is tinted violet.
B:
In a solution (1in 20),acidified with hydrochloric acid,hydrogen sulfide TSproduces an orange-red precipitate,which is soluble in ammonium sulfide TSand in 1Nsodium hydroxide.
C:
It responds to the test for Tartrate á191ñ.
Acidity or alkalinity—
Dissolve 1.0g in 50mLof carbon dioxide-free water,and titrate with 0.010Nhydrochloric acid or 0.010Nsodium hydroxide to a pHof 4.5:not more than 2.0mLis required.
Loss on drying á731ñ—
Dry it at 105
to constant weight:it loses not more than 2.7%of its weight.
to constant weight:it loses not more than 2.7%of its weight.
Arsenic—
Dissolve 100mg in 5mLof hydrochloric acid.Add 10mLof a recently prepared solution of 20g of stannous chloride in 30mLof hydrochloric acid.Mix,transfer to a color-comparison tube,and allow to stand for 30minutes.Viewed downward over a white surface,the color of the solution appears no deeper than that of a blank to which has been added 15µg of arsenic (0.015%).
Lead á251ñ:
not more than 0.002%.
Assay—
Dissolve about 500mg of Antimony Potassium Tartrate,accurately weighed,in 50mLof water,add 5g of potassium sodium tartrate,2g of sodium borate,and 3mLof starch TS,and immediately titrate with 0.1Niodine VSto the production of a persistent blue color.Each mLof 0.1Niodine is equivalent to 16.70mg of C8H4K2O12Sb2·3H2O.
Auxiliary Information—
Staff Liaison:Behnam Davani,Ph.D.,MBA,Senior Scientist
Expert Committee:(PA7)Pharmaceutical Analysis 7
USP28–NF23Page 169
Phone Number:1-301-816-8394