Antimony Sodium Tartrate
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Antimonate(2-),bis[µ-[2,3-dihydroxybutanedioato(4-)-O1,O2:O3,O4]]di-,disodium,stereoisomer.
Disodium bis[µ-[L-(+)-tartrato(4-)]]diantimonate(2-) [34521-09-0].
»Antimony Sodium Tartrate contains not less than 98.0percent and not more than 101.0percent of C8H4Na2O12Sb2,calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
Identification—
It responds to the tests for Antimony á191ñ,for Sodium á191ñ,and for Tartrate á191ñ.
Acidity or alkalinity—
Dissolve 1.0g in 50mLof carbon dioxide-free water,and titrate with 0.010Nhydrochloric acid or 0.010Nsodium hydroxide to a pHof 4.5:not more than 2.0mLis required.
Loss on drying á731ñ—
Dry it at 105
to constant weight:it loses not more than 6.0%of its weight.
to constant weight:it loses not more than 6.0%of its weight.
Arsenic,Method IIá211ñ:
8ppm.
Lead á251ñ:
not more than 0.002%.
Assay—
Dissolve about 500mg of Antimony Sodium Tartrate,accurately weighed,in 50mLof water,add 5g of potassium sodium tartrate,2g of sodium borate,and 3mLof starch TS,and immediately titrate with 0.1Niodine VSto the production of a persistent blue color.Each mLof 0.1Niodine is equivalent to 14.54mg of C8H4Na2O12Sb2.
Auxiliary Information—
Staff Liaison:Behnam Davani,Ph.D.,MBA,Senior Scientist
Expert Committee:(PA7)Pharmaceutical Analysis 7
USP28–NF23Page 169
Phone Number:1-301-816-8394