Oleovitamin Aand D
»Oleovitamin Aand Dis a solution of vitamin Aand vitamin Din fish liver oil or in an edible vegetable oil.The vitamin Dis present as ergocalciferol or cholecalciferol obtained by the activation of ergosterol or 7-dehydrocholesterol or from natural sources.Oleovitamin Aand Dcontains not less than 90.0percent of the labeled amounts of vitamins Aand D.
Packaging and storage— Preserve in tight containers,protected from light and air,preferably under an atmosphere of an inert gas.Store in a dry place.
Labeling— Label it to indicate the content of vitamin Ain mg per g.The vitamin Acontent may also be expressed in USP Vitamin A Units per g.Label it to show whether it contains ergocalciferol,cholecalciferol,or vitamin Dfrom a natural source.Label it to indicate also the vitamin Dcontent in µg per g.Its vitamin Dcontent may be expressed also in USP Vitamin D Units per g.
Organic volatile impurities,Method Vá467ñ: meets the requirements.
Solvent— Use dimethyl sulfoxide.
Assay for vitamin A— Proceed as directed under Vitamin A Assay á571ñ.
Assay for vitamin D— Accurately measure a portion of Oleovitamin Aand Dexpected to contain about the equivalent of 125to 250µg of vitamin D,but not more than 7.5mg of vitamin A,and proceed as directed for Chemical Methodunder Vitamin D Assay á581ñ.If the assay specimen contains less than the equivalent of 2.5µg of vitamin Dper g,or if the ratio of vitamin Ato vitamin Dexceeds 300to 1,proceed as directed for Biological Methodunder Vitamin D Assay á581ñ.
Auxiliary Information— Staff Liaison:Lawrence Evans,III,Ph.D.,Scientist
Expert Committee:(DSN)Dietary Supplements:Non-Botanicals
USP28–NF23Page 1415
Phone Number:1-301-816-8389
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