Ascorbic Acid
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L-Ascorbic acid.
L-Ascorbic acid [50-81-7].
»Ascorbic Acid contains not less than 99.0percent and not more than 100.5percent of C6H8O6.
Packaging and storage—
Preserve in tight,light-resistant containers.
Identification—
A:
Infrared Absorption á197Kñ.
B:
Asolution (1in 50)reduces alkaline cupric tartrate TSslowly at room temperature but more readily upon heating.
Specific rotation á781Sñ:
between +20.5
and +21.5,the optical rotation being measured immediately,following the preparation of the solution.
and +21.5,the optical rotation being measured immediately,following the preparation of the solution.
Test solution:
100mg per mL,in carbon dioxide-free water.
Residue on ignition á281ñ:
not more than 0.1%.
Heavy metals á231ñ—
Dissolve 1g in 25mLof water:the limit is 0.002%.
Organic volatile impurities,Method IVá467ñ:
meets the requirements.
Assay—
Dissolve about 400mg of Ascorbic Acid,accurately weighed,in a mixture of 100mLof water and 25mLof 2Nsulfuric acid.Add 3mLof starch TS,and titrate at once with 0.1Niodine VS.Each mLof 0.1Niodine is equivalent to 8.806mg of C6H8O6.
Auxiliary Information—
Staff Liaison:Lawrence Evans,III,Ph.D.,Scientist
Expert Committee:(DSN)Dietary Supplements:Non-Botanicals
USP28–NF23Page 178
Phone Number:1-301-816-8389