Squalane
;)
Tetracosane,2,6,10,15,19,23-hexamethyl-.
2,6,10,15,19,23-Hexamethyltetracosane [111-01-3].
»Squalane is a saturated hydrocarbon obtained by hydrogenation of squalene,an aliphatic triterpene occurring in some fish oils.
Packaging and storage—
Preserve in tight containers.
Identification,Infrared Absorption á197Fñ,on undried specimen.
Specific gravity á841ñ:
between 0.807and 0.810at 20
.
.
Acid value á401ñ:
not more than 0.2.
Iodine value á401ñ:
not more than 4.
Saponification value á401ñ:
not more than 2.
Refractive index á831ñ:
between 1.4510and 1.4525at 20.
.
Residue on ignition á281ñ:
not more than 0.5%.
Chromatographic purity—
Inject about 2µLof a 2in 100solution of Squalane in n-hexane into a suitable gas chromatograph,equipped with a flame-ionization detector.Under typical conditions the instrument contains a 3-mm ×1.8-m column packed with 3%phase G1on packing S1A,the column is temperature-programmed at about 6per minute from 130to 270,the injection port and the detector block are maintained at 280,and nitrogen is used as the carrier gas at a flow rate of 25mLper minute.Identify the squalane peak by comparison of the retention time with that of the main peak obtained by chromatographing a similar solution of USP Squalane RSunder the same conditions:the area of the squalane peak is not less than 97%of the sum of the areas of all of the peaks in the chromatogram.
per minute from 130to 270,the injection port and the detector block are maintained at 280,and nitrogen is used as the carrier gas at a flow rate of 25mLper minute.Identify the squalane peak by comparison of the retention time with that of the main peak obtained by chromatographing a similar solution of USP Squalane RSunder the same conditions:the area of the squalane peak is not less than 97%of the sum of the areas of all of the peaks in the chromatogram.
Auxiliary Information—
Staff Liaison:Catherine Sheehan,B.Sc.,Scientist
Expert Committee:(EMC)Excipients:Monograph Content
USP28–NF23Page 3087
Phone Number:1-301-816-8262