Sulisobenzone
;)
Benzenesulfonic acid,5-benzoyl-4-hydroxy-2-methoxy-.
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid [4065-45-6].
»Sulisobenzone contains not less than 95.0percent and not more than 105.0percent of C14H12O6S,calculated on the as-is basis.
Packaging and storage—
Preserve in tight,light-resistant containers.
Identification,Ultraviolet Absorption á197Uñ—
Solution:
10µg per mL.
Medium:
water.
Absorptivities do not differ by more than 3.0%.
Assay—
Accurately weigh about 1g of Sulisobenzone,and dissolve in 20mLof water in a conical flask.Add 200mLof dehydrated isopropyl alcohol,titrate a portion with 0.1Ntetrabutylammonium hydroxide VS,and determine the two endpoints potentiometrically.Calculate the amount,in mg,of C14H12O6Sin the portion of Sulisobenzone taken by the formula:
308.31C(2V1-V2),
in which 308.31is the empirical weight of sulisobenzone;Cis the concentration,in moles per liter,of the 0.1Ntetrabutylammonium hydroxide VS;and V1and V2are the volumes,in mL,of titrant needed to reach the first and second endpoints,respectively.
Auxiliary Information—
Staff Liaison:Lawrence Evans,III,Ph.D.,Scientist
Expert Committee:(PA6)Pharmaceutical Analysis 6
USP28–NF23Page 1840
Pharmacopeial Forum:Volume No.28(4)Page 1193
Phone Number:1-301-816-8389