Sugar-Free Suspension Structured Vehicle
»Prepare Sugar-Free Suspension Structured Vehicle as follows (see Pharmaceutical Compounding—Nonsterile Preparationsá795ñ):
Xanthan Gum 0.20g
Saccharin Sodium 0.20g
Potassium Sorbate 0.15g
Citric Acid 0.10g
Sorbitol 2.0g
Mannitol 2.0g
Glycerin 2.0mL
Purified Water,a sufficient quantity
to make 100mL
Transfer 30mLof Purified Water to a beaker,placing it on an electric hot plate and stirrer.Using moderate heat,stir to form a vortex,and slowly sprinkle the Xanthan Gum into the vortex.In a separate beaker,dissolve the Saccharin Sodium,Potassium Sorbate,and Citric Acid in 50mLof Purified Water.Using moderate heat,incorporate the Sorbitol,Mannitol,and Glycerin into this mixture.Add to this mixture the previously prepared Xanthan Gum dispersion.Add a sufficient quantity of Purified Water to obtain a final volume of 100mL,and mix.
Packaging and storage— Preserve in tight,light-resistant containers.Store at room temperature and avoid freezing.
Labeling— Label it to state that it must be well shaken before using.
Beyond-use date— Thirty days after the day on which it was compounded.
Auxiliary Information— Staff Liaison:Claudia C.Okeke,Ph.D.,Associate Director
Expert Committee:(CRX)Compounding Pharmacy
USP28–NF23Page 3097
Pharmacopeial Forum:Volume No.28(2)Page 428
Phone Number:1-301-816-8243