Tropicamide, chemical structure, molecular formula, Reference Standards

Tropicamide

C17H20N2O2 284.35

Benzeneacetamide,N-ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)-,(±)-.
(±)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide [1508-75-4].

»Tropicamide contains not less than 99.0percent and not more than 101.0percent of C17H20N2O2,calculated on the dried basis.

Packaging and storage— Preserve in tight,light-resistant containers.

USP Reference standards á11ñ— USP Tropicamide RS.

Identification—

A: Infrared Absorption á197Kñ.

B: Ultraviolet Absorption á197Uñ—

Solution: 25µg per mL.

Medium: 3Nhydrochloric acid.

Melting range,Class Iá741ñ: between 96

and 100

Loss on drying á731ñ— Dry about 500mg,accurately weighed,in vacuum over phosphorus pentoxide at 80

for 4hours:it loses not more than 0.5%of its weight.

Heavy metals,Method IIá231ñ: 0.002%.

Assay— Dissolve about 750mg of Tropicamide,accurately weighed,in 80mLof glacial acetic acid,add 4drops of crystal violet TS,and titrate with 0.1Nperchloric acid VSto a blue-green endpoint.Perform a blank determination,and make any necessary correction.Each mLof 0.1Nperchloric acid is equivalent to 28.44mg of C17H20N2O2.

Auxiliary Information— Staff Liaison:Lawrence Evans,III,Ph.D.,Scientist

Expert Committee:(PA6)Pharmaceutical Analysis 6

USP28–NF23Page 1998

Phone Number:1-301-816-8389