»Vanillin contains not less than 97.0percent and not more than 103.0percent of C8H8O3,calculated on the dried basis.
Packaging and storage Preserve in tight,light-resistant containers.
A: Infrared Absorption á197Kñ.
B: Ultraviolet Absorption á197Uñ
Solution: 8µg per mL.
Melting range á741ñ: between 81and 83.
Loss on drying á731ñ Dry it over silica gel for 4hours:it loses not more than 1.0%of its weight.
Residue on ignition á281ñ: not more than 0.05%.
Organic volatile impurities,Method IVá467ñ: meets the requirements.
Assay Transfer about 100mg of Vanillin,accurately weighed,to a 250-mLvolumetric flask,add methanol to volume,and mix.Pipet 2mLof this solution into a 100-mLvolumetric flask,add methanol to volume,and mix.Dissolve an accurately weighed quantity of USP Vanillin RSin methanol,and dilute quantitatively and stepwise with methanol to obtain a Standard solution having a known concentration of about 8µg per mL.Concomitantly determine the absorbances of both solutions in 1-cm cells at the wavelength of maximum absorbance at about 308nm,with a suitable spectrophotometer,using methanol as the blank.Calculate the quantity,in mg,of C8H8O3in the portion of Vanillin taken by the formula:
12.5C(AU/AS),in which Cis the concentration,in µg per mL,of USP Vanillin RSin the Standard solution;and AUand ASare the absorbances of the solution of Vanillin and the Standard solution,respectively.
Auxiliary Information Staff Liaison:Catherine Sheehan,B.Sc.,Scientist
Expert Committee:(EMC)Excipients:Monograph Content