Hydroxyethyl Cellulose
Cellulose,2-hydroxyethyl ether [9004-62-0].
»Hydroxyethyl Cellulose is a partially substituted poly(hydroxyethyl)ether of cellulose.It is available in several grades,varying in viscosity and degree of substitution,and some grades are modified to improve their dispersion in water.It may contain suitable anticaking agents.
Packaging and storage—
Preserve in well-closed containers.
Labeling—
The labeling indicates its viscosity,under specified conditions,in aqueous solution.The indicated viscosity may be in the form of a range encompassing 50%to 150%of the average value.
Identification—
A:
Stir about 1g into 100mLof water:it is dissolved completely to produce a colloidal solution that remains clear when heated to 60
.
.
B:
Place 1mLof the solution from Identificationtest Aon a glass plate,and allow the water to evaporate:a thin,self-sustaining film is formed.
C:
To 1mLof a solution (1in 2000)add 1mLof phenol solution (1in 20).Add 5mLof sulfuric acid,shake,and allow to cool:the color of the solution so obtained becomes orange.
Viscosity á911ñ—
When determined at the concentration and under the conditions specified in the labeling,its viscosity is not less than 50%and not more than 150%of the labeled viscosity,where stated as a single value,or it is between the maximum and minimum values,where stated as a range of viscosities.
pHá791ñ:
between 6.0and 8.5,in a solution (1in 100).
Loss on drying á731ñ—
Dry it at 105for 3hours:it loses not more than 10.0%of its weight.
for 3hours:it loses not more than 10.0%of its weight.
Residue on ignition á281ñ:
not more than 5.0%.
Lead á251ñ:
0.001%.
Heavy metals,Method IIá231ñ:
20µg per g.
Organic volatile impurities,Method IVá467ñ:
meets the requirements.
Auxiliary Information—
Staff Liaison:Justin Lane,B.S.,Scientific Associate
Expert Committee:(EMC)Excipients:Monograph Content
USP28–NF23Page 3017
Pharmacopeial Forum:Volume No.30(2)Page 709
Phone Number:1-301-816-8323