Acacia
»Acacia is the dried gummy exudate from the stems and branches of Acacia senegal(Linné)Willdenow or of other related African species of Acacia(Fam.Leguminosae).
Packaging and storage—
Preserve in tight containers.
Solubility and reaction—
Dissolve 1g in 2mLof water;the resulting solution flows readily and is acid to litmus.
Botanic characteristics—
Acacia—
Spheroidal tears up to 32mm in diameter or in angular fragments of white to yellowish white color.Is translucent or somewhat opaque from the presence of numerous minute fissures;very brittle,the fractured surface glassy and occasionally iridescent.Is almost odorless and produces a mucilaginous sensation on the tongue.
Flake Acacia—
White to yellowish white,thin flakes,appearing under the microscope as colorless,striated fragments.
Powdered Acacia—
White to yellowish white,angular microscopic fragments with only traces of starch or vegetable tissues present.
Granular Acacia—
White to pale yellowish white,fine granules.Under the microscope it appears as colorless,glassy,irregularly angular fragments up to 100µm in thickness,some of which exhibit parallel linear streaks.
Spray-dried Acacia—
White to off-white compacted microscopic fragments or whole spheres.
Identification—
To 10mLof a cold solution (1in 50)add 0.2mLof diluted lead subacetate TS:a flocculent,or curdy,white precipitate is formed immediately.
Microbial limits á61ñ—
It meets the requirements of the test for absence of Salmonellaspecies.
Water,Method IIIá921ñ—
Dry it at 105
for 5hours:it loses not more than 15.0%of its weight.For unground Acacia,crush it in a mortar until it passes through a No.40sieve,and mix the ground material before weighing the test specimen.
for 5hours:it loses not more than 15.0%of its weight.For unground Acacia,crush it in a mortar until it passes through a No.40sieve,and mix the ground material before weighing the test specimen.
Total ash á561ñ:
not more than 4.0%.
Acid-insoluble ash á561ñ:
not more than 0.5%.
Insoluble residue—
Dissolve 5.0g of powdered or finely ground Acacia in about 100mLof water in a 250-mLconical flask,add 10mLof 3Nhydrochloric acid,and boil gently for 15minutes.Filter by suction,while hot,through a tared filtering crucible,wash thoroughly with hot water,dry at 105for 1hour,and weigh.The weight of the residue thus obtained does not exceed 50mg.
for 1hour,and weigh.The weight of the residue thus obtained does not exceed 50mg.
Arsenic,Method IIá211ñ:
3ppm.
Lead á251ñ:
0.001%.
Heavy metals,Method IIá231ñ:
0.004%.
Starch or dextrin—
Boil a solution (1in 50),cool,and add iodine TS:no bluish or reddish color is produced.
Organic volatile impurities,Method Iá467ñ:
meets the requirements.
Tannin-bearing gums—
To 10mLof a solution (1in 50)add 0.1mLof ferric chloride TS:no blackish coloration or blackish precipitate is produced.
Auxiliary Information—
Staff Liaison:Catherine Sheehan,B.Sc.,Scientist
Expert Committee:(EMC)Excipients:Monograph Content
USP28–NF23Page 2947
Phone Number:1-301-816-8262