C9H14O6 218.21

1,2,3-Propanetriol triacetate.
Triacetin.
Glyceryl triacetate [102-76-1].

Packaging and storage— Preserve in tight containers.

USP Reference standards á11ñ— USP Triacetin RS.

Identification—

Specific gravity á841ñ: not less than 1.152and not more than 1.158.

Refractive index á831ñ: not less than 1.429and not more than 1.430.

Acidity— Dilute 25g of Triacetin,accurately weighed,with 50mLof neutralized alcohol,add 5drops of phenolphthalein TS,and titrate with 0.020Nsodium hydroxide:not more than 1.0mLof 0.020Nsodium hydroxide is required for neutralization.

Water,Method Iá921ñ: not more than 0.2%is found.

Assay— Transfer about 1g of Triacetin,accurately weighed,to a 250-mLboiling flask,add 50.0mLof 0.5Nalcoholic potassium hydroxide VS,connect the flask to a water-jacketed condenser,and reflux on a steam bath for 45minutes,swirling frequently.Cool,add 5drops of phenolphthalein TS,and titrate the excess alkali with 0.5Nhydrochloric acid VS.Perform a blank determination (see Residual Titrationsunder Titrimetry á541ñ).Each mLof 0.5Nalcoholic potassium hydroxide is equivalent to 36.37mg of C9H14O6.

Expert Committee:(PA7)Pharmaceutical Analysis 7

USP28–NF23Page 1957

Phone Number:1-301-816-8394